Whole slide pathology images from regional lymph node metastasis in colon adenocarcinoma produced at Region Gävleborg Clinical Pathology and Cytology department and Region Östergötland Clinical Pathology department. Annotations for AI training produced as part of AIDA clinical fellowship project investigating AI decision support in metastasis detection.

This dataset has been extended with a second collection series in the LNCO2 dataset using different collection and annotation parameters.

Keywords: Pathology, Whole slide imaging, Annotated, Lymph nodes, Cancer, Colon, Adenocarcinoma.

Sample images

Sample images with reduced image quality. Please click to preview.

Dataset information

Short name LNCO
Cite as Gordan Maras, Martin Lindvall, and Claes Lundstrom (2019) Regional lymph node metastasis in colon adenocarcinoma doi:10.23698/aida/lnco
Field Pathology
Organ Colon
Age span
Title Regional lymph node metastasis in colon adenocarcinoma
Author Gordan Maras
Martin Lindvall
Claes Lundstrom
Year 2019
DOI doi:10.23698/aida/lnco
Status Completed
Version 1.2.0
Scans 977
Annotations 7379
Size 373.66GB
Resolution 20x and 40x
Modality SM
Scanner Aperio Scanscope (20x)
Hamamatsu NanoZoomer (40x)
Stain Hematoxylin and eosin.
Phase
References
Access
constraints

Controlled access
Free for use in legal and ethical medical diagnostics research.
Please contact the copyright holder for terms of access.

AIDA BY license
Free for use within AIDA with attribution.

Copyright Copyright 2019 Linköping University, Claes Lundström
Download Please contact Gordan Maras, Joel Hedlund, or Claes Lundstrom to request access.

Annotation

ROI boxes around lymph nodes (positive, negative or unasssed) and detailed tumor polygons

See details below.

Annotation details

Labels

The following labels exists:

NOTE: tumor annotations are not exhaustive, meaning, there might be more tumor areas in lgl_roi_tumor lymph nodes than annotated with tumor annotations.

NOTE: Some roi_lgl_norm areas contain tumor cells that are from an accidental contamination of the glass during processing. This is normal during routine clinical work and a challenge that automated systems should deal with in an appropriate manner. This is a very easy task for human pathologists to discern.

NOTE: tumor regions not within a roi_lgl_* region should be assumed to be annotations of tumor in the the primary tumor. This can easily be verified visually, and the primary tumor is always on the initial blocks of the case (A..B…C etc)

Sampling procedure

Sampling procedure: Query for patients with confirmed adenocarcinomas that underwent colorectomy with subsequent lymphnode review as part of TNM-staging. Query selected N cases with a relatively high number of reported positive lymph nodes.

Source: Two medical clinics in Sweden.

Descriptive statistics

LNCO1
  patients: 39
  cases: 39
  images: 977
     median dimensions(WxH px): 49799 x 38729
     median resolution (micrometer per pixel): 0.4959
  annotations:
    number: 7379
    lymph node sections (roi) 1557
      which are negative 712
      which are positive 292
      which are unassessed 525
    images with at least one detailed tumor annotation: 165

License

Controlled access

Free for use in legal and ethical medical diagnostics research. Please contact the copyright holder for terms of access.

AIDA BY license

Copyright 2019 Linköping University, Claes Lundström

Permission to use, copy, modify, and/or distribute this data within Analytic Imaging Diagnostics Arena (AIDA) for any purpose with or without fee is hereby granted, provided that the above copyright notice and this permission notice appear in all copies, and that publications resulting from the use of this data cite the following works:

Gordan Maras, Martin Lindvall, and Claes Lundstrom (2019) Regional lymph node metastasis in colon adenocarcinoma doi:10.23698/aida/lnco.

THE DATA IS PROVIDED “AS IS” AND THE AUTHOR DISCLAIMS ALL WARRANTIES WITH REGARD TO THIS DATA INCLUDING ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS. IN NO EVENT SHALL THE AUTHOR BE LIABLE FOR ANY SPECIAL, DIRECT, INDIRECT, OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES WHATSOEVER RESULTING FROM LOSS OF USE, DATA OR PROFITS, WHETHER IN AN ACTION OF CONTRACT, NEGLIGENCE OR OTHER TORTIOUS ACTION, ARISING OUT OF OR IN CONNECTION WITH THE USE OR CHARACTERISTICS OF THIS DATA.